Computer Vision and Deep Learning for Liver Disease Diagnosis

A Systematic Review

Authors

  • Raad W. Salah Computer Science Department, University of Mosul, Mosul, Iraq.
  • Ielaf O. AbdulMajjed Computer Science Department, University of Mosul, Mosul, Iraq. https://orcid.org/0000-0002-8520-0233

DOI:

https://doi.org/10.61704/pr.544

Keywords:

Computer vision (CV), Artificial intelligence (AI), Liver Disease, Machine Learning (ML), Deep Learning (DL), NAFLD, ALD

Abstract

Liver diseases remain a major global health concern, posing significant diagnostic challenges due to their complex and heterogeneous nature. Conventional diagnostic methods rely heavily on clinical expertise and subjective interpretation, which can lead to variability and error. With recent advancements in artificial intelligence (AI), particularly in computer vision and deep learning (DL), there is a growing opportunity to improve the accuracy and efficiency of liver disease diagnosis. This review explores the applications of computer vision in the medical imaging analysis of liver diseases, including key processes such as image preprocessing, segmentation, lesion detection, and disease classification. The study also discusses the limitations of current techniques, critical challenges including data quality, model interpretability, and privacy, as well as emerging research directions. The integration of computer vision into clinical workflows holds great promise for enhancing early diagnosis, supporting clinical decision-making, and ultimately improving patient outcomes.

References

Afrin, S., Shamrat, F. J. M., Nibir, T. I., Muntasim, M. F., Moharram, M. S., Imran, M. M., & Abdulla, M. (2021). Supervised machine learning based liver disease prediction approach with LASSO feature selection. Bulletin of Electrical Engineering and Informatics.

Ahn, J. C., Connell, A., Simonetto, D. A., Hughes, C., & Shah, V. H. (2021). Application of artificial intelligence for the diagnosis and treatment of liver diseases. Hepatology, 73(6), 2546–2563.

Ali, A. M. A. A. (2024). A comprehensive review of liver disease prediction using big and artificial intelligence.

Ambade, A., Lowe, P., Kodys, K., Catalano, D., Gyongyosi, B., Cho, Y., ... & Szabo, G. (2019). Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis, and inflammation in mice. Hepatology, 69(3), 1105–1119.

Anter, A. M., & Abualigah, L. (2023). Deep federated machine learning-based optimization methods for liver tumor diagnosis: A review. Archives of Computational Methods in Engineering, 30(5), 3359–3378.

Asrani, S. K., Devarbhavi, H., Eaton, J., & Kamath, P. S. (2019). Burden of liver diseases in the world. Journal of Hepatology, 70(1), 151–171.

Brattain, L. J., Ozturk, A., Telfer, B. A., Dhyani, M., Grajo, J. R., & Samir, A. E. (2020). Image processing pipeline for liver fibrosis classification using ultrasound shear wave elastography. Ultrasound in Medicine & Biology, 46(10), 2667–2676.

Castera, L., Friedrich-Rust, M., & Loomba, R. (2019). Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease. Gastroenterology, 156(5), 1264–1281.

Cheemerla, S., & Balakrishnan, M. (2021). Global epidemiology of chronic liver disease. Clinical Liver Disease, 17(5), 365–370.

Cotter, T. G., & Rinella, M. (2020). Nonalcoholic fatty liver disease 2020: The state of the disease. Gastroenterology, 158(7), 1851–1864.

Ghazal, K. M., & Dahl, I. O. A. M. (2025). Applying the firefly algorithm to enhance the outcomes of multi-focus image fusion through anisotropic diffusion filters and bilateral filtering (ABF). AIP Conference Proceedings, 3264, 030009. https://doi.org/10.1063/5.0260508

Gul, S., Khan, M. S., Bibi, A., Khandakar, A., Ayari, M. A., & Chowdhury, M. E. (2022). Deep learning techniques for liver and liver tumor segmentation: A review. Computers in Biology and Medicine, 147, 105620.

Haleem, A., Ben Jabra, S., & Chainbi, W. (2025). Biometric fingerprint identification in low-quality samples using a hybrid features extraction method with deep learning. Evolving Systems, 16, 94. https://doi.org/10.1007/s12530-025-09726-5

Hoang, V. A., Nguyen, D. T., Bui, H. T., Le, T. L., Vu, D. H., Tran, B. G., ... & Vu, H. (2023, December). Comprehensive study of liver disease prediction using machine learning. In 2023 1st International Conference on Health Science and Technology (ICHST).

Hunter, S. (2019, March 18). What causes cirrhosis? News-Medical. Retrieved April 14, 2025, from https://www.news-medical.net/health/What-Causes-Cirrhosis.aspx

Hossen, M. S., Haque, I., Sarkar, P. R., Islam, M. A., Fahim, W. A., & Khatun, T. (2022, June). Examining the risk factors of liver disease: A machine learning approach. In 2022 7th International Conference on Communication and Electronics Systems (ICCES).

Kaur, S., Singla, J., Nkenyereye, L., Jha, S., Prashar, D., Joshi, G. P., ... & Islam, S. R. (2020). Medical diagnostic systems using artificial intelligence (AI) algorithms: Principles and perspectives. IEEE Access, 8, 228049–228069.

Kaya, E., & Yilmaz, Y. (2021). Metabolic-associated fatty liver disease (MAFLD): A multi-systemic disease beyond the liver. Journal of Clinical and Translational Hepatology, 10(2), 329.

Kim, D., & Kim, W. R. (2017). Nonobese fatty liver disease. Clinical Gastroenterology and Hepatology, 15(4), 474–485.

Kumar, S., Dhir, R., & Chaurasia, N. (2021, March). Brain tumor detection analysis using CNN: A review. In 2021 International Conference on Artificial Intelligence and Smart Systems (ICAIS) (pp. 1061–1067). IEEE.

Li, Y., Wang, X., Zhang, J., Zhang, S., & Jiao, J. (2022). Applications of artificial intelligence (AI) in researches on non-alcoholic fatty liver disease (NAFLD): A systematic review. Reviews in Endocrine and Metabolic Disorders, 23(3), 387–400.

Lonardo, A., Leoni, S., Alswat, K. A., & Fouad, Y. (2020). History of nonalcoholic fatty liver disease. International Journal of Molecular Sciences, 21(16), 5888.

Loomba, R., Friedman, S. L., & Shulman, G. I. (2021). Mechanisms and disease consequences of nonalcoholic fatty liver disease. Cell, 184(10), 2537–2564.

Lu, F., Meng, Y., Song, X., Li, X., Liu, Z., Gu, C., ... & Qi, X. (2024). Artificial intelligence in liver diseases: Recent advances. Advances in Therapy, 41(3), 967–990.

Montazeri, M., & Montazeri, M. (2024). Machine learning models for predicting the diagnosis of liver disease. Koomesh, 16(1), 53–59.

Mosquera, C., Lara, M. A. R., Díaz, F. N., Binder, F., & Benitez, S. E. (2023). Introducing computer vision into healthcare workflows. In Digital Health: From Assumptions to Implementations (pp. 43–62). Cham: Springer International Publishing.

Nam, D., Chapiro, J., Paradis, V., Seraphin, T. P., & Kather, J. N. (2022). Artificial intelligence in liver diseases: Improving diagnostics, prognostics, and response prediction. JHEP Reports, 4(4), 100443.

Najeeb, R. S. M., & Abdul Majjed, I. O. (2022). Brain tumor segmentation utilizing generative adversarial, ResNet, and U-Net deep learning. In Proceedings of the 8th International Conference on Contemporary Information Technology and Mathematics (ICCITM 2022), University of Mosul, Iraq.

Najeeb, R. S. M. (2023). 3D reconstruction of X-ray images from 2D images [Master’s thesis, University of Mosul]. University of Mosul Repository.

Nayantara, P. V., Kamath, S., Manjunath, K. N., & Rajagopal, K. V. (2020). Computer-aided diagnosis of liver lesions using CT images: A systematic review. Computers in Biology and Medicine, 127, 104035.

Powell, E. E., Wong, V. W. S., & Rinella, M. (2021). Non-alcoholic fatty liver disease. The Lancet, 397(10290), 2212–2224.

Rahman, A. S., Shamrat, F. J. M., Tasnim, Z., Roy, J., & Hossain, S. A. (2019). A comparative study on liver disease prediction using supervised machine learning algorithms. International Journal of Scientific & Technology Research, 8(11), 419–422.

Raghad, S. M. N. (2023). 3D reconstruction of X-ray images from 2D images [Master’s thesis, University of Mosul]. University of Mosul Repository.

Shaheamlung, G., & Kaur, H. (2021). The diagnosis of chronic liver disease using machine learning techniques. Information Technology in Industry, 9(2), 554–564.

Singh, J., Bagga, S., & Kaur, R. (2020). Software-based prediction of liver disease with feature selection and classification techniques. Procedia Computer Science, 167, 1970–1980.

Sookoian, S., & Pirola, C. J. (2019, May). Genetics of nonalcoholic fatty liver disease: From pathogenesis to therapeutics. In Seminars in Liver Disease (Vol. 39, No. 02, pp. 124–140). Thieme Medical Publishers.

Sontakke, S., Lohokare, J., & Dani, R. (2017). Diagnosis of liver diseases using machine learning. In 2017 International Conference on Emerging Trends & Innovation in ICT (ICEI) (pp. 129–133). IEEE. https://doi.org/10.1109/ETIICT.2017.7977023

Tomašev, N., Glorot, X., Rae, J. W., Zielinski, M., Askham, H., Saraiva, A., ... & Mohamed, S. (2019). A clinically applicable approach to continuous prediction of future acute kidney injury. Nature, 572(7767), 116–119.

Wu, C. C., Yeh, W. C., Hsu, W. D., Islam, M. M., Nguyen, P. A. A., Poly, T. N., ... & Li, Y. C. J. (2019). Prediction of fatty liver disease using machine learning algorithms. Computer Methods and Programs in Biomedicine, 170, 23–29.

Younis, M. C. (2021). Evaluation of deep learning approaches for identification of different corona-virus species and time series prediction. Computerized Medical Imaging and Graphics, 90, 101921. https://doi.org/10.1016/j.compmedimag.2021.101921

Zhou, L. Q., Wang, J. Y., Yu, S. Y., Wu, G. G., Wei, Q., Deng, Y. B., ... & Dietrich, C. F. (2019). Artificial intelligence in medical imaging of the liver. World Journal of Gastroenterology, 25(6), 672–689.

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Published

2025-10-29

How to Cite

Salah, R. W., & AbdulMajjed , I. O. (2025). Computer Vision and Deep Learning for Liver Disease Diagnosis: A Systematic Review . PROSPECTIVE RESEARCHES, 25(4), 69–77. https://doi.org/10.61704/pr.544

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